Description

Buy Meloxigard Meloxicam 20 mg/ml 100 ml solution for injection

Description of Meloxigard Meloxicam 20 mg/ml 100 ml:

The drug belongs to NSAIDs of the oxicam class, is a selective inhibitor of COX-2. It has anti-inflammatory, analgesic and antipyretic properties. The mechanism of action is associated with a decrease in the biosynthesis of prostaglandins as a result of inhibition of the enzymatic activity of COX-2, which is involved in the synthesis of prostaglandins in the focus of inflammation; has little effect on COX-1, reduces the risk of developing side effects.

It is a suspension from white to light yellow color.

Ingredients:

Active ingredient: 1 ml of the drug contains the active substance meloxicam – 20 mg;

Auxiliary components: sodium benzoate, glycerol, povidone K 30, xanthan gum, disodium phosphate dihydrate, sodium dihydrogen phosphate dihydrate, sodium dihydrate, citric acid, simethicone emulsion and purified water.

Pharmacological Properties of Meloxigard Meloxicam 20 mg/ml 100 ml:

Meloxigard has anti-inflammatory, analgesic and antipyretic properties. The mechanism of action is associated with a decrease in the biosynthesis of prostaglandins as a result of inhibition of the enzymatic activity of COX-2.

Relative bioavailability is almost 100%. After administration of the drug in a dose of 5 mg, the maximum concentration (max) is 1.62 μg / ml and is reached within approximately 60 minutes. Meloxicam binds well to plasma proteins, especially to albumin (99%). Penetrates into the synovial fluid, the concentration in the synovial fluid is about 50% of the plasma concentration. The volume of distribution (Vd) is low, on average it is 11 l.

Meloxicam is almost completely metabolized in the liver with the formation of 4 inactive derivatives. The main metabolite, 5-carboxymeloxicam (60% of the dose), is formed by oxidation of the intermediate metabolite 5-hydroxymethylmeloxicam, which is also excreted, but in smaller quantities (9% of the dose).

It is excreted equally with feces and urine, mainly in the form of metabolites. In the unchanged form, less than 5% of the daily dose is excreted in the feces; in the urine, the drug is found in unchanged form only in a small amount. The elimination half-life (T ½) is 20 hours. Clearance averages 8 ml/min. Meloxicam shows linear pharmacokinetics in doses of 7.5-15 mg when administered. Hepatic or renal failure of moderate severity does not significantly affect the pharmacokinetics of meloxicam.

Indications for use Meloxigard Meloxicam 20 mg/ml 100 ml:

Meloxigard 2% is used as an anti-inflammatory and analgesic drug in cattle for diarrhea in combination with rehydration therapy, for acute respiratory infections, purulent-catarrhal mastitis in combination with appropriate antibacterial therapy, and also for inflammatory processes of the musculoskeletal system. Pigs with disorders of the musculoskeletal system associated with an inflammatory process of non-infectious etiology, in the treatment of postpartum sepsis and mastitis-metritis-agalactia syndrome in combination with appropriate antibacterial drugs. For horses with chronic and acute diseases of the musculoskeletal system and colic as an anti-inflammatory and analgesic agent.

For dogs and cats with acute and chronic diseases of the musculoskeletal system, accompanied by severe pain and inflammation (fractures, traumatic arthropathies, sprains of ligaments and tendons, osteoarthritis, chronic degenerative joint diseases, etc.), as well as for the reduction of postoperative pain in acute and chronic diseases of the musculoskeletal system.

Contraindications for use Meloxigard Meloxicam 20 mg/ml 100 ml:

The use of the drug is prohibited for calves under one week of age, stallions under six weeks of age, foals or lactating mares, animals with liver ulcers, cardiovascular system disorders, kidney function disorders and hemorrhagic manifestations, with increased sensitivity to the active substance.

The simultaneous use of the drug with GCS, other non-steroidal anti-inflammatory drugs, as well as anticoagulants is prohibited.

Special Instruction:

Slaughter of animals for meat is allowed no earlier than 5 days after the last use of the drug. Milk can be used for food 3 days after using the drug. The meat of animals forcibly killed before the expiration of the specified period can be used as fodder for fur animals.

When carrying out manipulations with the drug, it is forbidden to drink, smoke and eat food and after using the drug should wash your hands with soap.

Storage:

In the manufacturer’s closed packaging, separately from food and feed, in a dry place protected from light and inaccessible to children, at a temperature of 10 °C to 25 °C.

Shelf Life:

3 years. After the first opening of the bottle – no more than 28 days.