Triptorelin is a synthetic decapeptide similar to natural GnRH (gonadotropin-releasing hormone).
The results of preclinical and clinical studies have shown that, after initial stimulation, prolonged use of triptorelin suppresses the secretion of gonadotropins with subsequent suppression of testicular and ovarian function.
At the beginning of treatment with Diphereline (11.25 mg), levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in the blood may increase, with a corresponding increase in the level (flare) of testosterone in men and estradiol in women. With continued treatment, the levels of LH and FSH decrease, which is accompanied by a decrease in the levels of testosterone and estradiol to post-castration values, which were achieved within about 20 days after injection and persisted until the release of the active substance.
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