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It is used in a complex of assisted reproductive technologies (including for in vitro fertilization) to induce the final maturation of follicles and luteinization after stimulation with gonadotropins.
Ovitrelle is a medicinal product of human hCG produced by recombinant DNA technology. HCG alfa shares an amino acid sequence with human chorionic gonadotropin (hCG) isolated from urine. On cells of the ovarian folder (and granulosa), human chorionic gonadotropin binds to transmembrane LH/CG receptors, which also bind luteinizing hormone (LH).
The main pharmacodynamic action of the drug in women is the renewal of oocyte meiosis, rupture of the follicle (ovulation), the formation of the corpus luteum and the production of progesterone and estradiol by the corpus luteum. In women, human chorionic gonadotropin acts like an LH surge that triggers ovulation.
Ovitrelle is used to initiate the final maturation of follicles and early luteinization after the use of drugs that stimulate follicular growth.
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