Metronidazole belongs to the 5-nitroimidazole group. The mechanism of action of metronidazole is the biochemical reduction of the 5-nitro group of metronidazole by intracellular transport proteins of anaerobic bacteria and protozoa. The reduced 5-nitro group of metronidazole interacts with the DNA of a microbial cell, inhibiting the synthesis of its nucleic acids, which leads to the death of the microorganism. Effective against Trichomonas vaginalis, Gardnerella vaginalis, Giardia intestinalis, Entamoeba histolytica, Bacteroides spp. (Bacteroides fragilis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides vulgatus), Fusobacterium spp., Veillonela spp., some Gram-positive bacteria (Eubacterium spp., Clostridium spp., Peptococcus spp., Peptostreptococcus spp.)
Treatment of cattle, sheep, pigs, fur-bearing animals, dogs, cats and poultry with trichomoniasis, dysentery, diarrhea, colitis, stomatitis, as well as diseases of the respiratory system, genitourinary system, gastrointestinal tract and skin caused by microorganisms sensitive to metronidazole.
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